Protein Modification Reagents
Medchemexpress LLC DBCO-mPEG (MW 30kDa) | 90.0% | 25 MG
DBCO-mPEG (MW 30kDa) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Functions as a click chemistry reagent
- Features a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC PEG(2000)-C-DMG | 1443687-74-8 | 98.0% | 2600 g/mol (approx.) | 10 MG
PEG(2000)-C-DMG is a polyethylene glycol-conjugated lipid used as a PEG-lipid component in liposomes and lipid nanoparticles (LNPs). It helps stabilize particle surfaces, reduce protein adsorption, and modulate circulation time for nucleic acid delivery applications such as siRNA and mRNA formulations. Typical form is a white to off-white solid with solubility in DMSO (requires sonication).
- Improves particle stability and circulation time.
- Reduces serum protein adsorption and aggregation.
- Suitable for lipid nanoparticle and liposome formulations for nucleic acid delivery.
- Supplied as a solid that is soluble in DMSO with sonication.
- High purity for research applications.
Meso Scale Discovery R-PLEX Human Elastase-2 ASYQP
The R-PLEX Human Elastase 2 Assay from Meso Scale Discovery is a multiplex immunoassay panel that measures Elastase 2 levels in human serum plasma and cell culture supernatants This assay uses electrochemiluminescence (ECL) detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements The assay can be used to monitor Elastase 2 levels as a biomarker and requires only 50 L of sample per well The panel allows simultaneous measurement of Elastase 2 along with other biomarkers in human samples
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-MMAE | 98.0% | 1450.76 | 25 MG
Mal-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate designed for Antibody-Drug Conjugate (ADC) research. It comprises a degradable ADC linker and a potent tubulin inhibitor.
- Contains a degradable ADC linker, Mal-PEG4-Val-Cit-PAB
- Contains a potent tubulin inhibitor, MMAE
Medchemexpress LLC DSPE-PEG-Amine, MW 5000 | 95.0% | 100 MG
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound is intended for research use only. PROTACs function by connecting two ligands, one for an E3 ubiquitin ligase and another for a target protein, to exploit the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Designed for selective degradation of target proteins
- Average molecular weight of 5000
- Appears as a solid, white to off-white material
Medchemexpress LLC Hydroxylamine, O,O'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis- | 98627-72-6 | 96.0% | C10H24N2O6 | 250 MG
Bis-aminooxy-PEG4 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs consist of two distinct ligands joined by a linker, one targeting an E3 ubiquitin ligase and the other for a specific target protein. This mechanism leverages the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 25 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds designed to degrade target proteins by exploiting the intracellular ubiquitin-proteasome system; they achieve this by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Degrades target proteins
- Exploits intracellular ubiquitin-proteasome system
- Connects a ligand for an E3 ubiquitin ligase with a ligand for the target protein
![Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-(PEG4-alkyne)oxy]phenyl ethyl ester | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204059.png-250.jpg)
Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-(PEG4-alkyne)oxy]phenyl ethyl ester | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 100 MG
PC Alkyne-PEG4-NHS ester is a cleavable PEG4 linker bearing an alkyne functional group and an N-hydroxysuccinimide (NHS) ester. It is used to attach payloads to amine-containing biomolecules via NHS chemistry and to enable azide-alkyne click reactions for bioconjugation and linker assembly.
- Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition.
- Features an NHS ester for efficient amine conjugation.
- PEG4 spacer provides solubility and flexibility for linker design.
- Typical applications include antibody-drug conjugate and PROTAC linker synthesis.
- Provided with analytical purity suitable for research use.
Sigma Aldrich Fine Chemicals Biosciences Pepsin from porcine gastric mucosa | 9001-75-6 | MFCD00081840 | 10 g
Pepsin from porcine gastric mucosa | Mol Wt: 35 kDa | 9001-75-6 | MFCD00081840 | 10 g
Medchemexpress LLC 4-Arm PEG-SCM MW 20 100mg
4-Arm PEG-SCM (MW 20000) is a multi-arm PEG derivative that can be used for peptide modification and drug delivery[1]
PEPTIDE SOLUTIONS LLC Biotin-PEG(4)-SS-Tyramide | 50mg
Biotin-PEG(4)-SS-Tyramide | MW: 774.02 | 50mg
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum release of rat epididymal adipocytes and hepatocytes tested (for methodology see Type II and Type IV), Type VIII, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid | 9001-12-1 | MFCD00130830 | 100mg
Collagenase from Clostridium histolyticum release of rat epididymal adipocytes and hepatocytes tested (for methodology see Type II and Type IV), Type VIII, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solidMW: | 9001-12-1 | MFCD00130830 | 100mg
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3965455 DL-DITHIOTHREITOL SOLUTION10ML
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | >95.0% | 406.39 g/mol | C19H22N2O8 | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204285.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | >95.0% | 406.39 g/mol | C19H22N2O8 | 500 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC)